optic nerve transection injury model Search Results


optic nerve transection injury model  (Dawley Inc)
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Dawley Inc optic nerve transection injury model
Etomidate promots retinal ganglion cells (RGCs) survival at 7 days after optic nerve <t>transection.</t> (A) Surviving RGCs with FluoroGold-labeled. Compared with the normal control (NC) group, surviving RGCs of the ONT group were decreased. Etomidate significantly reduced the loss of RGCs. Scale bars: 200 µm. (B) Quantitative result of surviving RGCs densities. There were significantly more surviving RGCs in the ET group than in the ONT group; however, the average density of RGCs in both groups was significantly lower than that in the normal control group. The data are expressed as the mean ± SD ( n = 6 per group). * P < 0.05, vs . normal control group; # P < 0.05, vs . ONT group (one-way analysis of variance followed by Tukey’s test). ONT: Optic nerve transection; ET: ONT + etomidate.
Optic Nerve Transection Injury Model, supplied by Dawley Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Etomidate promots retinal ganglion cells (RGCs) survival at 7 days after optic nerve transection. (A) Surviving RGCs with FluoroGold-labeled. Compared with the normal control (NC) group, surviving RGCs of the ONT group were decreased. Etomidate significantly reduced the loss of RGCs. Scale bars: 200 µm. (B) Quantitative result of surviving RGCs densities. There were significantly more surviving RGCs in the ET group than in the ONT group; however, the average density of RGCs in both groups was significantly lower than that in the normal control group. The data are expressed as the mean ± SD ( n = 6 per group). * P < 0.05, vs . normal control group; # P < 0.05, vs . ONT group (one-way analysis of variance followed by Tukey’s test). ONT: Optic nerve transection; ET: ONT + etomidate.

Journal: Neural Regeneration Research

Article Title: Etomidate affects the anti-oxidant pathway to protect retinal ganglion cells after optic nerve transection

doi: 10.4103/1673-5374.259627

Figure Lengend Snippet: Etomidate promots retinal ganglion cells (RGCs) survival at 7 days after optic nerve transection. (A) Surviving RGCs with FluoroGold-labeled. Compared with the normal control (NC) group, surviving RGCs of the ONT group were decreased. Etomidate significantly reduced the loss of RGCs. Scale bars: 200 µm. (B) Quantitative result of surviving RGCs densities. There were significantly more surviving RGCs in the ET group than in the ONT group; however, the average density of RGCs in both groups was significantly lower than that in the normal control group. The data are expressed as the mean ± SD ( n = 6 per group). * P < 0.05, vs . normal control group; # P < 0.05, vs . ONT group (one-way analysis of variance followed by Tukey’s test). ONT: Optic nerve transection; ET: ONT + etomidate.

Article Snippet: To reveal its mechanism, we established the optic nerve transection injury model by transecting 1 mm behind the left eyeball of adult male Sprague-Dawley rats.

Techniques: Labeling, Control

Etomidate affects the retinal NO (A), MDA (B), and GSH (C) levels in rats with optic nerve transection. The data are expressed as the mean ± SD ( n = 6 per group). * P < 0.05, vs . normal control (NC) group; # P < 0.05, vs . ONT group (one-way analysis of variance followed by Tukey’s test). NO: Nitric oxide; MDA: malonaldehyde; GSH: glutathione; ONT: optic nerve transection; ET: ONT + etomidate; h: hours; d: days.

Journal: Neural Regeneration Research

Article Title: Etomidate affects the anti-oxidant pathway to protect retinal ganglion cells after optic nerve transection

doi: 10.4103/1673-5374.259627

Figure Lengend Snippet: Etomidate affects the retinal NO (A), MDA (B), and GSH (C) levels in rats with optic nerve transection. The data are expressed as the mean ± SD ( n = 6 per group). * P < 0.05, vs . normal control (NC) group; # P < 0.05, vs . ONT group (one-way analysis of variance followed by Tukey’s test). NO: Nitric oxide; MDA: malonaldehyde; GSH: glutathione; ONT: optic nerve transection; ET: ONT + etomidate; h: hours; d: days.

Article Snippet: To reveal its mechanism, we established the optic nerve transection injury model by transecting 1 mm behind the left eyeball of adult male Sprague-Dawley rats.

Techniques: Control